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found that the highest quartile concentrations of leucine and isoleucine were associated with increased CVD risk, with hazard ratios of 1.70 and 2.09, respectively ( A meta-analysis by Wang et al

bioRxiv Preprint

2A, B and 5C) such as EMPEROR-Preserved phase 3 trial [127], are of particular interest, as no agent of any class has previously shown a clear and unambiguous benefit for this indication [128]